Costantini Lab

What we do

We build living tissues and porous materials by combining microfluidics, 3D (bio)printing and data-driven design.

• Microfluidic biofabrication

  We combine microfluidic printheads with extrusion, wet-spinning and light-based 3D printing to pattern cells and materials with micrometre precision, including multi-material and gradient constructs.

• Skeletal muscle & musculoskeletal models

  We engineer functional skeletal muscle, tendon and myotendinous-junction tissues, both as in vitro models and as implants for volumetric muscle loss.

• Functionally graded porous materials

  Microfluidic foaming and emulsion templating give us precise control over pore size and gradients, while machine-learning-aided design links architecture to mechanical performance.

• Vascularisation & regenerative biomaterials

  We build perfusable microvascular networks and bioactive hydrogels for tissue repair and, in our FNP FIRST TEAM project, bioresorbable dressings for negative-pressure wound therapy.

Latest News

Recent announcements and highlights from the lab.

• 25 September 2026A big milestone, a proud moment, and a new chapter begins for Maria Celeste Tirelli!
• 24 March 2026Our new website is live!

Research Projects

Current and recent funded research projects from the lab.

SONATA BIS 11 – National Science Centre (NCN)Active

Diffusion of rods and flexible polymers in complex fluids

View project

FIRST TEAM – Foundation for Polish ScienceActive

Inverse design-assisted biodegradable modular dressings for negative pressure wound healing

View project

SONATINA 9 – National Science Centre (NCN)Active

Optomechanical Transduction for in vitro maturation and functional enhancement of biofabricated skeletal MUScles

View project

Recent papers

Our latest original research articles and reviews.

• Original Research

  MLATE V3: An Open-Source Multi-Tissue AI Framework for Data-Driven Optimization of 3D-Printed and Bioprinted Scaffolds

  Biofabrication • 2026

  DOI / Link for “MLATE V3: An Open-Source Multi-Tissue AI Framework for Data-Driven Optimization of 3D-Printed and Bioprinted Scaffolds” (opens in a new tab)
• Original Research

  A comprehensive toolkit for manipulation and analysis of sprouting capillary networks based on magnetic ordering of multiple EC-coated microcarriers and their use in tissue modelling and drug testing

  Lab on a Chip • 2026

  DOI / Link for “A comprehensive toolkit for manipulation and analysis of sprouting capillary networks based on magnetic ordering of multiple EC-coated microcarriers and their use in tissue modelling and drug testing” (opens in a new tab)
• Original Research

  Circulating extracellular vesicles from early-stage lung cancer patients trigger endothelial activation to drive pre-metastatic niche formation through synergistic miR-29a and C4A signaling

  Journal of Experimental & Clinical Cancer Research • 2026

  DOI / Link for “Circulating extracellular vesicles from early-stage lung cancer patients trigger endothelial activation to drive pre-metastatic niche formation through synergistic miR-29a and C4A signaling” (opens in a new tab)